FAM3C antibody (AA 151-227) (Alexa Fluor 555)

Catalog No. ABIN896523

Product Details anti-FAM3C Antibody (Alexa Fluor 555)

Target: FAM3C (Family with Sequence Similarity 3, Member C (FAM3C))

Binding Specificity: AA 151-227

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM3C antibody is conjugated to Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM3C

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FAM3C

Target: FAM3C (Family with Sequence Similarity 3, Member C (FAM3C))

Alternative Name: FAM3C (FAM3C Products)

Synonyms: ILEI antibody, D6Wsu176e antibody, Ilei antibody, wu:fb99h11 antibody, wu:fi35h03 antibody, zgc:55444 antibody, zgc:77090 antibody, family with sequence similarity 3 member C antibody, family with sequence similarity 3, member C antibody, family with sequence similarity 3 member C L homeolog antibody, fam3c antibody, FAM3C antibody, Fam3c antibody, fam3c.L antibody

Background:

Synonyms: Fam3c, FAM3C_HUMAN, family with sequence similarity 3, member C, GS3786,ILEI, Interleukin-like EMT inducer, Predicted osteoblast protein, Protein FAM3C.

Background: ILEI is a 227 amino acid, ubiquitously expressed protein containing an amino-terminal signal peptide. Elevated levels of ILEI translation are observed in oncogenic, Ras-transformed mammary epithelial cells and epithelial to mesenchymal transition (Emt) as well as tumor growth and metastasis. Also, overexpression of ILEI results in loss of ZO-1, a protein involved in tight junctions, and expression of cytoplasmic E-cadherin, which has been shown to influence loss of polarity and invasiveness. Due to this evidence, it is suspected that ILEI cooperates with oncogenic Ras to cause TGF-independent Emt and its overexpression is correlated with the invasion, metastasis and survival in a variety of cancers.

Gene ID: 10447