Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PIDD antibody (AA 551-650) (HRP)

PIDD Reactivity: Rat ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal HRP
Catalog No. ABIN905092
  • Target See all PIDD Antibodies
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Binding Specificity
    • 14
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-650
    Reactivity
    • 20
    • 19
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 33
    • 3
    Rabbit
    Clonality
    • 33
    • 3
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIDD antibody is conjugated to HRP
    Application
    • 14
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human LRDD/PIDD
    Isotype
    IgG
    Top Product
    Discover our top product PIDD Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Alternative Name
    LRDD (PIDD Products)
    Synonyms
    1200011D09Rik antibody, AU042446 antibody, Pidd antibody, LRDD antibody, Lrdd antibody, p53 induced death domain protein 1 antibody, p53-induced death domain protein 1 antibody, Pidd1 antibody, PIDD1 antibody
    Background

    Synonyms: Leucine rich repeats and death domain containing, Leucine-rich repeats and death domain containing, MGC16925, p53-induced protein with a death domain, PIDD, DKFZp434D229, PIDD_HUMAN.

    Background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.

    Pathways
    p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
You are here:
Support