PTPRJ antibody (AA 850-890) (Alexa Fluor 555)

Catalog No. ABIN912532

Product Details anti-PTPRJ Antibody (Alexa Fluor 555)

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Binding Specificity: AA 850-890

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRJ antibody is conjugated to Alexa Fluor 555

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PTPRJ

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PTPRJ

Target: PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))

Alternative Name: Dep1/Ptprj (PTPRJ Products)

Synonyms: HAAP antibody, CD148 antibody, DEP1 antibody, HPTPeta antibody, R-PTP-ETA antibody, SCC1 antibody, AI450271 antibody, BET antibody, Byp antibody, DEP-1 antibody, PTPbeta2 antibody, Ptpb2 antibody, RPTPJ antibody, Scc-1 antibody, Scc1 antibody, PTPRJ antibody, acid phosphatase 1 antibody, protein tyrosine phosphatase, receptor type J antibody, protein tyrosine phosphatase, receptor type, J antibody, ACP1 antibody, PTPRJ antibody, Ptprj antibody, EUBREC_2762 antibody

Background:

Synonyms: DEP1, SCC1, CD148, HPTPeta, R-PTP-ETA, Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, Density-enhanced phosphatase 1, DEP-1, HPTP eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J, PTPRJ

Background: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration, through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation, through KDR dephosphorylation. Negative regulator of EGFR signaling pathway, through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Gene ID: 5795

UniProt: Q12913

Pathways: EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling