C14orf166 antibody (AA 151-244) (Alexa Fluor 647)

Catalog No. ABIN913759

Product Details anti-C14orf166 Antibody (Alexa Fluor 647)

Target: C14orf166 (Chromosome 14 Open Reading Frame 166 (C14orf166))

Binding Specificity: AA 151-244

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C14orf166 antibody is conjugated to Alexa Fluor 647

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RLLM1/C14orf166

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for C14orf166

Target: C14orf166 (Chromosome 14 Open Reading Frame 166 (C14orf166))

Alternative Name: RLLM1 (C14orf166 Products)

Synonyms: CGI99 antibody, CLE antibody, CLE7 antibody, LCRP369 antibody, RLLM1 antibody, C14orf166 antibody, C10H14orf166 antibody, RNA transcription, translation and transport factor antibody, chromosome 5 C14orf166 homolog antibody, RNA transcription, translation and transport factor S homeolog antibody, zgc:56576 antibody, RTRAF antibody, C5H14orf166 antibody, rtraf.S antibody, zgc:56576 antibody

Background:

Synonyms: CGI 99, CGI99, CLE, Homeobox prox 1, RLLM1, Chromosome 14 open reading frame 166, CLE7, LCRP369, RLL mot containing 1, CN166_HUMAN.

Background: CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5 % of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Gene ID: 51637