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SLC29A4 antibody (AA 401-500) (Alexa Fluor 647)

SLC29A4 Reactivity: Human, Rat WB, FACS, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN915555
  • Target See all SLC29A4 Antibodies
    SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))
    Binding Specificity
    • 15
    • 9
    • 9
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivity
    • 55
    • 20
    • 7
    • 4
    • 4
    • 4
    Human, Rat
    Host
    • 52
    • 3
    Rabbit
    Clonality
    • 53
    • 2
    Polyclonal
    Conjugate
    • 17
    • 5
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC29A4 antibody is conjugated to Alexa Fluor 647
    Application
    • 55
    • 31
    • 17
    • 13
    • 12
    • 12
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Dog,Cow,Pig,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SLC29A4
    Isotype
    IgG
    Top Product
    Discover our top product SLC29A4 Primary Antibody
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))
    Alternative Name
    SLC29A4 (SLC29A4 Products)
    Synonyms
    zgc:158679 antibody, ENT4 antibody, PMAT antibody, mPMAT antibody, solute carrier family 29 (equilibrative nucleoside transporter), member 4 antibody, solute carrier family 29 member 4 antibody, solute carrier family 29 (nucleoside transporters), member 4 antibody, slc29a4 antibody, SLC29A4 antibody, Slc29a4 antibody
    Background

    Synonyms: ENT4, PMAT, Equilibrative nucleoside transporter 4, hENT4, Plasma membrane monoamine transporter, Solute carrier family 29 member 4, SLC29A4, PSEC0113

    Background: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH , with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

    Gene ID
    222962
    UniProt
    Q7RTT9
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