PAXIP1 antibody (N-Term)

Catalog No. ABIN928548

Product Details anti-PAXIP1 Antibody

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAXIP1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Frog, Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: PAXIP1 antibody was raised in rabbit using the N terminal of PAXIP1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PAXIP1 Blocking Peptide, catalog no. 33R-5988, is also available for use as a blocking control in assays to test for specificity of this PAXIP1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PAXIP1

Target: PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))

Alternative Name: PAXIP1 (PAXIP1 Products)

Synonyms: CAGF29 antibody, PACIP1 antibody, PAXIP1L antibody, PTIP antibody, TNRC2 antibody, wu:fa04b06 antibody, zgc:92593 antibody, cagf28 antibody, cagf29 antibody, k14 antibody, pacip1 antibody, paxip1l antibody, ptip antibody, tnrc2 antibody, D5Ertd149e antibody, PAX interacting protein 1 antibody, PAX interacting (with transcription-activation domain) protein 1 antibody, PAX interacting protein 1 L homeolog antibody, PAXIP1 antibody, paxip1 antibody, paxip1.L antibody, Paxip1 antibody

Background: PAXIP1 functions as a key component of the DNA damage response, and phosphoserine or phosphothreonine-specific binding modules. PAXIP1 recognizes substrates phosphorylated by the kinases ataxia telangiectasia-mutated (ATM), ataxia telangiectasia and RAD3-related (ATR) in response to gamma irradiation. It may play a role in PAX2-dependent transcriptional regulation. PAXIP1 plays a role in early development, most probably in cell proliferation. Synonyms: Polyclonal PAXIP1 antibody, Anti-PAXIP1 antibody, PAX interacting, with transcription-activation domain protein 1 antibody, PTIP antibody, TNRC2 antibody, CAGF28 antibody, CAGF29 antibody, PACIP1 antibody, PAXIP1L antibody, FLJ41049 antibody.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response