p170 Glycoprotein antibody

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Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Immunogen MDR cell line CHrC5 from chinese hamster ovary
Clone JSB-1
Isotype IgG1
Specificity Human MDR glycoprotein p170
Application Notes IHC(P) , Pre-teatment of paraffin sections with Unmasking Fluid P required! neat Positive Control: Liver or renal carcinoma
Restrictions For Research Use only
Format Liquid
Buffer stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 100 immunohistochemical tests (100 ul working solution / test)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Hamada, Tsuruo: "Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase." in: The Journal of biological chemistry, Vol. 263, Issue 3, pp. 1454-8, 1988 (PubMed).

Ueda, Cardarelli, Gottesman, Pastan: "Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 9, pp. 3004-8, 1987 (PubMed).

Kartner N,Evernden-Porelle D,Bradley G,Ling V: "Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies." in: Nature, Vol. 316, Issue 6031, pp. 820-3, 1985 (PubMed).