T-Complex Protein 1 (TCP1) antibody

Antigen: T-Complex Protein 1 (TCP1)

Clonality: Monoclonal (4A4)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN93812

Additional Information

Alternative name: p63 Protein

Immunogen: Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63

Format: Liquid

Isotype: IgG2a

Clone: 4A4

Specificity: P63 (6 Isotypes)

Application Details

Application Notes: IHC(P) , Pre-treatment of formaldehyde-fixed tissue with Tris-buffered EDTA solution pH 9 (Art.-No. DE006) or Unmasking Fluid G (Art.-No. DE007) 40 min at 100°C neat Positive Control: Normal prostate tissue or skin

Buffer: stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 100 immunohistochemical tests (100 ul working solution / test)

Storage: 2-8°C

Research Area: Cancer, Signaling, Apoptosis/Necrosis

Restrictions: For Research Use only

Images

Detection of p63 protein in nucleus of epidermis stained with anti-p63 antibody

Publications

Yang, Kaghad, Wang et al.: "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities." in: Molecular cell, Vol. 2, Issue 3, pp. 305-16, 1998 (PubMed).

Celli J, Duijf P, Hamel BC et al.: "Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome." in: Cell, Vol. 99, Issue 2, pp. 143-53, 1999 (PubMed).

Signoretti, Waltregny, Dilks et al.: "p63 is a prostate basal cell marker and is required for prostate development." in: The American journal of pathology, Vol. 157, Issue 6, pp. 1769-75, 2000 (PubMed).

Pelosi G, Pasini F, Olsen Stenholm C et al.: "p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?" in: J Pathol, Vol. 198, Issue 1, pp. 100-9, 2002 (PubMed).