P63 Protein antibody

Antigen: P63 Protein

Clonality: Monoclonal (4A4)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN93814

Additional Information

Immunogen: Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63

Format: Ready to use

Isotype: IgG2a  (Matching secondary antibodies)

Clone: 4A4

Description: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 50 immunohistochemical tests (100 ul working solution / test). Use appropriate antibody diluent.

Specificity: P63 (6 Isotypes)

Application Details

Application Notes: IHC (C,P) , Antigen unmasking after formaldehyde fixation by heat treatment in EDTA solution pH 9 . neat Positive Control: Normal prostate tissue or skin (epidermis)

Buffer: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 50 immunohistochemical tests (100 µl working solution / test)

Storage: 2-8°C

Research Area: Cancer, Signaling, Apoptosis/Necrosis

Restrictions: For Research Use only

Publications

Publications: Yang, Kaghad, Wang et al.: "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities." in: Molecular cell, Vol. 2, Issue 3, pp. 305-16, 1998 (PubMed).

Celli J, Duijf P, Hamel BC et al.: "Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome." in: Cell, Vol. 99, Issue 2, pp. 143-53, 1999 (PubMed).

Signoretti, Waltregny, Dilks et al.: "p63 is a prostate basal cell marker and is required for prostate development." in: The American journal of pathology, Vol. 157, Issue 6, pp. 1769-75, 2000 (PubMed).

Pelosi G, Pasini F, Olsen Stenholm C et al.: "p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?" in: J Pathol, Vol. 198, Issue 1, pp. 100-9, 2002 (PubMed).