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p63 Protein + HMW Cytokeratin (Basal Cell Marker) antibody

Details for Product No. ABIN93859, Supplier: Log in to see
Antigen
Reactivity
Human
2
Host
Mouse
2
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
2
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Immunogen Recombinant human p63 protein (aa 1-205) and cytokeratin extract of human stratum corneum
Clone 4A4-34betaE12
Isotype IgG1, IgG2a
Specificity Nuclear p63 and cytoplasmic high molecular weight cytokeratins
Research Area Cancer, Signaling, Apoptosis/Necrosis
Application Notes IHC(P) , Positive Control: Normal prostate tissue or skin
Restrictions For Research Use only
Format Liquid
Concentration 40+40
Buffer stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 100 immunohistochemical tests (100 ul working solution / test)
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Browne TJ, Hirsch MS, Brodsky G et al.: "Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens." in: Hum Pathol, Vol. 35, Issue 12, pp. 1462-8, 2004 (PubMed).

Weinstein MH, Signoretti S, Loda M: "Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells." in: Mod Pathol, Vol. 15, Issue 12, pp. 1302-8, 2002 (PubMed).

Signoretti, Waltregny, Dilks et al.: "p63 is a prostate basal cell marker and is required for prostate development." in: The American journal of pathology, Vol. 157, Issue 6, pp. 1769-75, 2000 (PubMed).

Yang, Lecksell, Gaudin et al.: "Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer." in: The American journal of surgical pathology, Vol. 23, Issue 2, pp. 147-52, 1999 (PubMed).