Basal Cellmarker Cocktail P63 Protein/HMW Cytokeratin antibody

Antigen: Basal Cellmarker Cocktail P63 Protein/HMW Cytokeratin

Clonality: Monoclonal (4A4-34betaE12)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN93860

Additional Information

Alternative name: Basal Cellmarker Cocktail p63 Protein + HMW Cytokeratin

Immunogen: Recombinant human p63 protein (aa 1-205) and cytokeratin extract of human stratum corneum

Format: Ready to use

Isotype: IgG1, IgG2a  (Matching secondary antibodies)

Clone: 4A4-34betaE12

Description: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 50 immunohistochemical tests (100 ul working solution / test). Use appropriate antibody diluent.

Specificity: Nuclear p63 and cytoplasmic high molecular weight cytokeratins

Application Details

Application Notes: IHC(P) , neat , Positive Control: Normal prostate tissue or skin

Concentration: 0,5+0,5

Buffer: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for at least 50 immunohistochemical tests (100 µl working solution / test)

Storage: 2-8°C

Research Area: Cancer, Signaling, Apoptosis/Necrosis

Restrictions: For Research Use only

Publications

Publications: Yang XJ, Lecksell K, Gaudin P et al.: "Rare expression of high-molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer." in: Am J Surg Pathol, Vol. 23, Issue 2, pp. 147-52, 1999 (PubMed).

Signoretti, Waltregny, Dilks et al.: "p63 is a prostate basal cell marker and is required for prostate development." in: The American journal of pathology, Vol. 157, Issue 6, pp. 1769-75, 2000 (PubMed).

Weinstein MH, Signoretti S, Loda M: "Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells." in: Mod Pathol, Vol. 15, Issue 12, pp. 1302-8, 2002 (PubMed).

Browne TJ, Hirsch MS, Brodsky G et al.: "Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens." in: Hum Pathol, Vol. 35, Issue 12, pp. 1462-8, 2004 (PubMed).