Glutamate Receptor, Metabotropic 1 (GRM1) antibody (PE)

Details for Product No. ABIN93990
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Antigen
Synonyms fj39d05, wu:fj39d05, si:ch211-51a19.1, Glura, mGlutR, GB18621, GPRC1A, MGLU1, MGLUR1, SCAR13, 4930455H15Rik, ENSMUSG00000075319, Gm10828, Gprc1a, mGluR1, nmf373, rcw, wobl
Reactivity
Human, Non-Human Primate
(116), (64), (60), (34), (30), (29), (29), (6), (5), (3)
Host
Mouse
(110), (16), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(6), (5), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(68), (36), (33), (30), (28), (24), (13), (10), (3), (3), (2), (1), (1)
Pubmed 8 references available
Quantity 100 tests
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Catalog No. ABIN93990
421.08 $
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Immunogen Normal human peripheral blood granulocytes
Clone LNK16
Isotype IgG1
Specificity The antibody LNK16 reacts with CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA, 50-65 kDa, expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB, 48 kDa, mainly expressed on neutrophils).HLDA V, WS Code M MA069HLDA V, WS Code NK NK50
Characteristics The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Alternative Name GRM1
Background CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms -, FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µL reagent / 100 µL of whole blood or 10^6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Reconstitution No reconstitution is necessary.
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8 °C. Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
Supplier Images
anti-Glutamate Receptor, Metabotropic 1 (GRM1) antibody (PE) Flow Cytometry analysis
General Mathison, Befus, Davison et al.: "Modulation of neutrophil function by the tripeptide feG." in: BMC immunology, Vol. 4, pp. 3, 2003 (PubMed).

Lin, Liu, Chen et al.: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Congy-Jolivet, Bolzec, Ternant et al.: "Fc gamma RIIIa expression is not increased on natural killer cells expressing the Fc gamma RIIIa-158V allotype." in: Cancer research, Vol. 68, Issue 4, pp. 976-80, 2008 (PubMed).

Mathison, Christie, Davison: "The tripeptide feG inhibits leukocyte adhesion." in: Journal of inflammation (London, England), Vol. 5, pp. 6, 2008 (PubMed).

Chen, Freedman: "CD16+ gammadelta T cells mediate antibody dependent cellular cytotoxicity: potential mechanism in the pathogenesis of multiple sclerosis." in: Clinical immunology (Orlando, Fla.), Vol. 128, Issue 2, pp. 219-27, 2008 (PubMed).

Kahn, Moergelin, Shannon et al.: "Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response." in: PLoS pathogens, Vol. 4, Issue 9, pp. e1000149, 2008 (PubMed).

Meknache, Joensson, Laurent et al.: "Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 4, pp. 2542-50, 2009 (PubMed).

Mehrle, Watzl, von Lilienfeld-Toal et al.: "Comparison of phenotype of gammadelta T cells generated using various cultivation methods." in: Immunology letters, Vol. 125, Issue 1, pp. 53-8, 2009 (PubMed).

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