CD1a Molecule (CD1A) antibody

Details for Product No. ABIN94018, Supplier: Log in to see
Antigen
  • CD1A
  • CD1.1
  • CD1.2
  • CD1A2
  • CD1
  • FCB6
  • HTA1
  • R4
  • T6
  • CD1B
  • AI747460
  • Cd1a
  • Cd1d
  • Ly-38
  • CD1b molecule
  • CD1 antigen
  • CD1a molecule
  • CD1d1 antigen
  • CD1B
  • CD1.1
  • CD1A
  • Cd1d1
Alternatives
anti-Human CD1a Molecule antibody for Cytometry by Time of Flight
Reactivity
Human
503
38
28
15
13
9
5
1
1
1
1
1
Host
Mouse
390
117
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
40
34
24
15
14
12
11
11
11
10
9
9
9
9
9
7
7
7
3
3
3
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
363
173
172
161
135
119
108
107
41
15
4
3
3
2
1
1
1
1
Options
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Immunogen Human thymocytes
Clone HI149
Isotype IgG1
Specificity The antibody HI149 reacts with CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.
The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
HLDA V, WS Code CD01.01
Purification Purified by protein A
Purity > 95 % (by SDS-PAGE)
Alternative Name CD1A (CD1A Antibody Abstract)
Background CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Research Area Surface Receptors of Immune Cells, Adaptive Immunity, CD Antigens, Immunology
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Mayer, Irschick, Moser, Wurm, Huemer, Romani, Irschick: "Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers." in: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4459-67, 2007 (PubMed).

Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." in: International immunology, Vol. 19, Issue 11, pp. 1271-9, 2007 (PubMed).

Perros, Dorfmüller, Souza, Durand-Gasselin, Mussot, Mazmanian, Hervé, Emilie, Simonneau, Humbert: "Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension." in: The European respiratory journal, Vol. 29, Issue 3, pp. 462-8, 2007 (PubMed).

Demedts, Brusselle, Vermaelen, Pauwels: "Identification and characterization of human pulmonary dendritic cells." in: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, 2005 (PubMed).

Chen, Murakami, Oppenheim, Howard: "Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking." in: Blood, Vol. 106, Issue 7, pp. 2409-16, 2005 (PubMed).

Kirsch, Zeyda, Stuhlmeier, Grisar, Smolen, Watschinger, Stulnig, Hörl, Zlabinger, Säemann: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function." in: Arthritis research & therapy, Vol. 7, Issue 3, pp. R694-703, 2005 (PubMed).

Hunger, Sieling, Ochoa, Sugaya, Burdick, Rea, Brennan, Belisle, Blauvelt, Porcelli, Modlin: "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells." in: The Journal of clinical investigation, Vol. 113, Issue 5, pp. 701-8, 2004 (PubMed).

McKenna, Asplund, Kroft: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry." in: Leukemia & lymphoma, Vol. 45, Issue 2, pp. 277-85, 2004 (PubMed).

Säemann, Parolini, Böhmig, Kelemen, Krieger, Neumüller, Knarr, Kammlander, Hörl, Diakos, Stuhlmeier, Zlabinger: "Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells." in: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 238-46, 2002 (PubMed).

Background publications Favali, Tavares, Claruencio, Barral, Barral-Netto, Brodskyn: "Leishmania amazonensis infection impairs differentiation and function of human dendritic cells." in: Journal of leukocyte biology, Vol. 82, Issue 6, pp. 1401-6, 2007 (PubMed).

Raftery, Winau, Kaufmann, Schaible, Schönrich: "CD1 antigen presentation by human dendritic cells as a target for herpes simplex virus immune evasion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6207-14, 2006 (PubMed).

Hiromatsu, Dascher, Sugita, Gingrich-Baker, Behar, LeClair, Brenner, Porcelli: "Characterization of guinea-pig group 1 CD1 proteins." in: Immunology, Vol. 106, Issue 2, pp. 159-72, 2002 (PubMed).

Sugita, Grant, van Donselaar, Hsu, Rogers, Peters, Brenner: "Separate pathways for antigen presentation by CD1 molecules." in: Immunity, Vol. 11, Issue 6, pp. 743-52, 2000 (PubMed).