CD2 Molecule (CD2) antibody (Dyomics 647)

Details for Product No. ABIN94023
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(341), (155), (88), (18), (15), (15), (15), (10), (9), (6), (5), (5), (3), (3)
(381), (125), (76)
Clonality (Clone)
Monoclonal ()
Dyomics 647
(83), (78), (60), (11), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(407), (108), (85), (83), (76), (57), (55), (23), (20), (16), (10), (10), (9), (8), (4), (2), (2), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 100 tests
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Immunogen Human peripheral T cells.
Clone MEM-65
Isotype IgG1
Specificity The antibody MEM-65 recognizes an unique epitope of CD2, a 50 kDa glycoprotein presenton the human peripheral blood T-lymphocytes and NK cells, also expressed by allthymocytes.HLDA VI, WS Code T 6T-012
Alternative Name CD2 (CD2 Antibody Abstract)
Background CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interactionwith CD58 stabilizes adhesion between T cells and antigen presenting or target cells.Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within thetwo-dimensional cell-cell interface to provide tight adhesion. Morover, T cell activationinduces increased CD2 expression and its lateral mobility, making easier contact betweenCD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites ofcell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reducesintestinal inflammation and helps to control infection.
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Restrictions For Research Use only
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Muhammad, Schiller, Forster et al.: "Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 7672-80, 2009 (PubMed).

Espagnolle, Depoil, Zaru et al.: "CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse." in: International immunology, Vol. 19, Issue 3, pp. 239-48, 2007 (PubMed).

Ilangumaran, Briol, Hoessli: "CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes." in: Blood, Vol. 91, Issue 10, pp. 3901-8, 1998 (PubMed).

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Catalog No. ABIN94023
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