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CD6 antibody (CD6) Biotin

Details for Product anti-CD6 Antibody No. ABIN94207, Supplier: Login to see New
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(174), (43), (38), (8), (5)
(179), (49), (12)
Clonality (Clone)
Monoclonal ()
This CD6 antibody is conjugated to Biotin
(27), (27), (17), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(164), (96), (68), (50), (35), (32), (31), (26), (11), (7), (6), (5)
Pubmed 2 references available
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Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Immunogen Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cellsfollowed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gelcorresponding to the 100 kDa zone).
Clone MEM-98
Isotype IgG1
Specificity The MEM-98 antibody reacts with CD6, a 100-130 kDa single chain transmembraneglycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acutelymphocytic leukemia cells.
Alternative Name CD6 (CD6 Antibody Abstract)
Background CD6, also known as T12, is a member of the scavenger receptor superfamily found on Tand B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interactswith its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as acoreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAMmediated cell adhesion is also important for T cell proliferation. CD6 may exert some itsfunctions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6has antiapoptotic role in chronic lymphocytic leukemia B cells.
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Biotinylated antibody is designed for indirect immunofluorescence analysis by FlowCytometry. Suggested working dilution is 1: 50.Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
General Castro, Oliveira, Nunes et al.: "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4351-61, 2007 (PubMed).

Hassan, Simmonds, Clarkson et al.: "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76." in: Molecular and cellular biology, Vol. 26, Issue 17, pp. 6727-38, 2006 (PubMed).

Catalog No. ABIN94207

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