Tumor Necrosis Factor Ligand Superfamily Member 10 (TNFSF10) antibody

Antigen: Tumor Necrosis Factor Ligand Superfamily Member 10 (TNFSF10)

Synonyms: TL2, APO2L, CD253, TRAIL, Apo-2L, Ly81, Trail, APO-2L, AI448571, A330042I21Rik, TRAIL-LIKE, TNFSF10, tl2, apo2l, cd253, trail, apo-2l, trail1, xtrail1

Clonality: Monoclonal (2E5)

Host: Mouse

Reactivity: Human

Application: Flow Cytometry (FACS), Functional Studies (Func)

Catalog no.: ABIN94484

Additional Information

Alternative name: CD253 / TRAIL

Immunogen: Recombinant soluble fragment (aa 95-281) of human TRAIL.

Format: Azide Free

Isotype: IgG1

Clone: 2E5

Description: Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is atype II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activatesrapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achievedthrough binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5(CD262 / TRAIL-R2).

Specificity: The antibody 2E5 reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapidapoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also inmany other tissues. This antibody does not react with: Mouse, Other not tested.

Application Details

Application Notes: Functional Application: The antibody 2E5 has high neutralizing activity for human TRAIL in biological assays. Flow Cytometry

Concentration: 1 mg/ml

Purity: > 95% (by SDS-PAGE)

Purification: Purified from ascites by protein-A affinity chromatography.

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized.

Storage: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Research Area: Cancer, Apoptosis/Necrosis

Restrictions: For Research Use only

Images

Induction of apoptosis