Amyloid antibody

Antigen: Amyloid

Clonality: Monoclonal (BAM-10)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN95019

Additional Information

Immunogen: A synthetic beta-amyloid peptide (1-40) conjugated to KLH.

Format: Ascites (prediluted)

Isotype: IgG1

Clone: BAM-10

Specificity: This antibody reacts with beta-amyloid protein. This antibody stains Amyloid plaques within the cortex, and Amyloid deposits in blood vessels. Beta-amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis and in Gram-Parkinson dementia complex. The presence to a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used a pathological marker for a disease state and presents the major criterion for the diagnosis of Alzheimer's disease at autopsy.

Application Details

Application Notes: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Suitable for formalin/paraffin tissues. Positive Control: Brain. Cellular localization: Cytoplasmic

Concentration: 100ug/ml approximately

Purification: Ascites (prediluted)

Buffer: This antibody is supplied as diluted ascites containing sodium azide as preservative.

Storage: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Research Area: Neurology, Alzheimer's Disease

Restrictions: For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Publications

Tanzi, McClatchey, Lamperti et al.: "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease." in: Nature, Vol. 331, Issue 6156, pp. 528-30, 1988 (PubMed).