Actin-Like 7b (Actl7b) (N-Term), (AA 68-97) antibody

Details for Product No. ABIN950264
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Antigen
Synonyms ACTL7B, Tact1
Epitope
N-Term, AA 68-97
(15), (7), (7), (6), (4), (2), (2), (2), (1), (1)
Reactivity
Human
(30), (18), (6)
Host
Rabbit
(28), (12), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(41), (28), (4), (4), (2)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN950264
357.50 $
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Immunogen KLH conjugated synthetic peptide between 68-97 amino acids from the N-terminal region of human ACTL7B
Specificity This antibody reacts to ACTL7B.
Purification Affinity chromatography on Protein A
Alternative Name ACTL7B
Background The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Alternate names: Actin-like protein 7B, Actin-like-7-beta
Gene ID 10880
NCBI Accession NP_006677
Research Area Signaling, Cytoskeleton, Microfilaments
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Chadwick, Mull, Helbling et al.: "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31." in: Genomics, Vol. 58, Issue 3, pp. 302-9, 1999 (PubMed).

Klionsky, Ohsumi: "Vacuolar import of proteins and organelles from the cytoplasm." in: Annual review of cell and developmental biology, Vol. 15, pp. 1-32, 2000 (PubMed).

Hisano, Ohta, Nishimune et al.: "Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells." in: Nucleic acids research, Vol. 31, Issue 16, pp. 4797-804, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

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