anti-AIM2 antibody (Absent in Melanoma 2) (N-Term)

Details for Product anti-AIM2 Antibody No. ABIN950314
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Synonyms AIM2, PYHIN4, Gm1313, Ifi210
N-Term, AA 11-40
(18), (15), (15), (13), (13), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(127), (19), (18), (1), (1)
(80), (35), (14)
This AIM2 antibody is un-conjugated
(6), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(109), (74), (25), (17), (13), (10), (9), (8), (4), (3), (3), (2), (1), (1)
Pubmed 6 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2
Isotype Ig
Specificity This antibody reacts to AIM2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AIM2 (AIM2 Antibody Abstract)
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2
Gene ID 9447
NCBI Accession NP_004824
Research Area Cancer, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Patsos, Germann, Gebert et al.: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Hauschild, Schadendorf: "[Working group of the Dermatologic Oncology]." in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Vol. 7, Issue 8, pp. 726-7, 2009 (PubMed).

Fernandes-Alnemri, Yu, Datta et al.: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, 2009 (PubMed).

Hornung, Ablasser, Charrel-Dennis et al.: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Woerner, Kloor, Schwitalle et al.: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Cresswell, Clarke, Jackson et al.: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).

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Catalog No. ABIN950314
$ 357.50
Plus shipping costs $45.00
0.4 mL
$ 357.50

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