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AIM2 antibody (Absent in Melanoma 2) (N-Term)

Details for Product anti-AIM2 Antibody No. ABIN950314, Supplier: Log in to see
Antigen
  • AIM2
  • PYHIN4
  • Gm1313
  • Ifi210
  • absent in melanoma 2
  • AIM2
  • Aim2
Alternatives
anti-Human AIM2 antibody for Western Blotting
Epitope
N-Term, AA 11-40
16
15
13
12
9
8
8
4
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
187
28
24
2
1
1
1
Host
Rabbit
90
61
39
Clonality
Polyclonal
Conjugate
This AIM2 antibody is un-conjugated
8
8
8
8
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
158
81
34
34
23
13
12
12
4
2
2
1
1
Options
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Immunogen KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2
Isotype Ig
Specificity This antibody reacts to AIM2.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AIM2 (AIM2 Antibody Abstract)
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2
Gene ID 9447
NCBI Accession NP_004824
Research Area Cancer, Transcription Factors
Pathways Activation of Innate immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-AIM2 antibody (Absent in Melanoma 2) (N-Term) (ABIN950314) AIM2 Antibody (N-term) flow cytometric analysis of MCF-7 cells (bottom histogram) com...
Western Blotting (WB) image for anti-AIM2 antibody (Absent in Melanoma 2) (N-Term) (ABIN950314) Western blot analysis of AIM2 Antibody (N-term) in MCF-7, HL-60, K562, Hela cell line...
Background publications Patsos, Germann, Gebert, Dihlmann: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Hauschild, Schadendorf: "[Working group of the Dermatologic Oncology]." in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Vol. 7, Issue 8, pp. 726-7, 2009 (PubMed).

Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, 2009 (PubMed).

Woerner, Kloor, Schwitalle, Youmans, Doeberitz, Gebert, Dihlmann: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).