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AKR1C4 antibody (Aldo-keto Reductase Family 1 Member C4) (N-Term)

Details for Product anti-AKR1C4 Antibody No. ABIN950323, Supplier: Log in to see
Antigen
  • 3-alpha-HSD
  • C11
  • CDR
  • CHDR
  • DD-4
  • DD4
  • HAKRA
Epitope
N-Term, AA 10-39
31
15
10
5
4
2
1
1
Reactivity
Human
75
10
10
Host
Rabbit
41
19
14
1
Clonality
Polyclonal
Conjugate
This AKR1C4 antibody is un-conjugated
3
3
3
3
3
3
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
70
42
20
12
11
3
2
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human AKR1C4.
Isotype Ig
Specificity This antibody reacts to AKR1C4.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name AKR1C4 (AKR1C4 Antibody Abstract)
Background AKR1C4 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.Synonyms: 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type I, Aldo-keto reductase family 1 member C4, CDR, CHDR, Chlordecone reductase, DD-4, DD4, Dihydrodiol dehydrogenase 4, HAKRA
Gene ID 1109
NCBI Accession NP_001809
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-AKR1C4 antibody (Aldo-keto Reductase Family 1 Member C4) (N-Term) (ABIN950323) AKR1C4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35 µg/l...
Background publications Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).