Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) (C-Term), (AA 629-660) antibody

Details for Product No. ABIN950354
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Antigen
Synonyms 12R-LOX, ARCI2, Aloxe2, e-LOX2, ALOX12B, MGC107915, MGC85124
Epitope
C-Term, AA 629-660
(2), (1), (1)
Reactivity
Human
(5)
Host
Rabbit
(3), (3)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(3), (2), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN950354
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 629-660 amino acids from the C-terminal region of human ALOX12B
Specificity This antibody reacts to ALOX12B.
Purification Affinity chromatography on Protein A
Alternative Name ALOX12B
Background This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R- hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
Alternate names: 12R type, 12R-LOX, 12R-lipoxygenase, Arachidonate 12-lipoxygenase
Gene ID 242
NCBI Accession NP_001130
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Agarwal, Achari, Praveen et al.: "Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways." in: Experimental dermatology, Vol. 18, Issue 11, pp. 939-46, 2009 (PubMed).

Vahlquist, Bygum, Gånemo et al.: "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients." in: The Journal of investigative dermatology, Vol. 130, Issue 2, pp. 438-43, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Hosts (3), (3)
Reactivities (5)
Applications (3), (2), (1), (1), (1)
Epitopes (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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