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Details for Product No. ABIN950354

Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) (C-Term), (AA 629-660) antibody

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Antigen
Synonyms 12R-LOX, ARCI2, Aloxe2, e-LOX2, ALOX12B, MGC107915, MGC85124
Epitope
»Alternatives C-Term, AA 629-660
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN950354
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 629-660 amino acids from the C-terminal region of human ALOX12B
Specificity This antibody reacts to ALOX12B.
Purification Affinity chromatography on Protein A
Alternative Name ALOX12B
Background This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R- hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
Alternate names: 12R type, 12R-LOX, 12R-lipoxygenase, Arachidonate 12-lipoxygenase
Gene ID 242
NCBI Accession NP_001130
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Agarwal, Achari, Praveen et al.: "Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways." in: Experimental dermatology, Vol. 18, Issue 11, pp. 939-46, 2009 (PubMed).

Vahlquist, Bygum, Gånemo et al.: "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients." in: The Journal of investigative dermatology, Vol. 130, Issue 2, pp. 438-43, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Alternatives for antigen "Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B)", type "Antibodies"
Hosts (5), (3)
Reactivities (7)
Applications (4), (3), (3), (3), (1), (1)
Epitopes (3), (3), (2), (1), (1)
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