Actinin, alpha 2 (ACTN2) (C-Term), (AA 750-779) antibody

Details for Product No. ABIN950370
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Antigen
Synonyms MGC89234, ACTN2, 1110008F24Rik, CMD1AA, wu:fd44c03, zgc:123223
Epitope
C-Term, AA 750-779
(13), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(26), (22), (9), (5), (4), (3), (3), (2), (2), (2), (2)
Host
Rabbit
(39), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(43), (15), (13), (11), (9), (8), (5), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN950370
357.50 $
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Immunogen KLH conjugated synthetic peptide between 750-779 amino acids from the C-terminal region of human ACTN2
Specificity This antibody reacts to Alpha-actinin-2.
Purification Affinity chromatography on Protein A
Alternative Name Alpha-actinin-2 / ACTN2
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.
Alternate names: Alpha actinin skeletal muscle isoform 2, F-actin cross-linking protein
Gene ID 88
NCBI Accession NP_001094
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).

Chiu, Bagnall, Ingles et al.: "Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis." in: Journal of the American College of Cardiology, Vol. 55, Issue 11, pp. 1127-35, 2010 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Saus, Brunet, Armengol et al.: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Zimmerman, Cox, Lakdawala et al.: "A novel custom resequencing array for dilated cardiomyopathy." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 5, pp. 268-78, 2010 (PubMed).

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