APBA2 antibody (Middle Region)

Catalog No. ABIN950450

Product Details anti-APBA2 Antibody

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Binding Specificity: AA 314-344, Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APBA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to APBA2.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 314-344 amino acids from the Central region of human APBA2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for APBA2

Target: APBA2 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 2 (APBA2))

Alternative Name: APBA2 (APBA2 Products)

Background: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: Adapter protein X11beta, Amyloid beta A4 precursor protein-binding family A member 2, MINT2, Mint-2, Neuron-specific X11L protein, Neuronal Munc18-1-interacting protein 2, X11L

Gene ID: 321

NCBI Accession: NP_001123886

Pathways: Synaptic Vesicle Exocytosis