Asialoglycoprotein Receptor 1 (ASGR1) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN950533
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Antigen
Synonyms ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1, Asgr, Asgr-1, ASGR, RATRHL1, RHL1
Epitope
N-Term, AA 1-30
(12), (9), (1), (1), (1)
Reactivity
Human
(44), (22), (19), (17), (17), (1)
Host
Rabbit
(42), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (18), (14), (4), (4), (3), (2), (2), (2)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
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Catalog No. ABIN950533
357.50 $
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ASGR1
Specificity This antibody reacts to ASGR1.
Purification Affinity chromatography on Protein A
Alternative Name ASGR1
Background Partially deglycosylated plasma glycoproteins and immunoglobulin IgA2 allotypes are efficiently and specifically removed from circulation by a receptor-mediated process. The asialoglycoprotein receptor binds to desialylated (galactosyl-terminal) glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic- sorting organelle where the receptor and ligand dissociate. Then the receptor is recycled back to the cell surface and the ligand is transported to the lysosomes for degradation. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alternate names: ASGP-R 1, ASGPR 1, Asialoglycoprotein receptor 1, Hepatic lectin H1
Gene ID 432
NCBI Accession NP_001184145
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Yik, Saxena, Weigel et al.: "Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40844-52, 2002 (PubMed).

Oh, Yang, Hahn et al.: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, 2005 (PubMed).

Yang, Wang, Tian et al.: "Fibronectin and asialoglyprotein receptor mediate hepatitis B surface antigen binding to the cell surface." in: Archives of virology, Vol. 155, Issue 6, pp. 881-8, 2010 (PubMed).

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