ATPase, H+ Transporting, Lysosomal 70kDa, V1 Subunit A (ATP6V1A) (AA 447-477), (Middle Region) antibody

Details for Product No. ABIN950568
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Antigen
Synonyms
ATP6V1A, atp6v1al, zgc:63516, An02g10440, AO090102000349, ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1, atp6a1, atp6v1a1, ho68, v1a, va68, vma1, vpp2, AA959968, ATP6a1, Atp6n1, Atp6n1a, Atpv0a1, Vpp-1, Vp ... show more
ATP6V1A, atp6v1al, zgc:63516, An02g10440, AO090102000349, ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1, atp6a1, atp6v1a1, ho68, v1a, va68, vma1, vpp2, AA959968, ATP6a1, Atp6n1, Atp6n1a, Atpv0a1, Vpp-1, Vpp1, AI647066, Atp6a1, Atp6a2, Atp6v1a1, CG12403, Dmel\CG12403, V-ATPase, Vha, Vha-68-1, Vha68, vha67-2, vha68-1 show less
Epitope
AA 447-477, Middle Region
(7), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(37), (20), (17), (15), (13), (13), (3), (3), (2), (2), (2), (2), (1), (1)
Host
Rabbit
(34), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(30), (17), (12), (10), (8), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN950568
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Immunogen KLH conjugated synthetic peptide between 447~477 amino acids from the Central region of human ATP6V1A
Isotype Ig
Specificity This antibody reacts to ATP6V1A.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name ATP6V1A
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.Synonyms: ATP6A1, ATP6V1A1, V-ATPase 69 kDa subunit, V-ATPase subunit A, V-type proton ATPase catalytic subunit A, VPP2, Vacuolar ATPase isoform VA68, Vacuolar proton pump subunit alpha
Gene ID 523
NCBI Accession NP_001681
Research Area Signaling, Metabolism
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Morel: "Neurotransmitter release: the dark side of the vacuolar-H+ATPase." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 95, Issue 7, pp. 453-7, 2003 (PubMed).

Ahmed, Forsberg, Bergsten: "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 3, pp. 931-40, 2005 (PubMed).

Martins-de-Souza, Gattaz, Schmitt et al.: "Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia." in: Journal of psychiatric research, Vol. 43, Issue 11, pp. 978-86, 2009 (PubMed).

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