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UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 6 (B4GALT6) (C-Term), (AA 322-350) antibody

Details for Product No. ABIN950594
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Antigen
Synonyms B4Gal-T6, beta4Gal-T6, AA536803, AU022389
Epitope
C-Term, AA 322-350
(8), (7)
Reactivity
Human
(10), (2)
Host
Rabbit
(11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(11), (7), (7), (7), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN950594
357.50 $
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Immunogen KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human B4GALT6
Specificity This antibody reacts to B4GALT6.
Purification Affinity chromatography on Protein A
Alternative Name B4GALT6
Background This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose, all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.
Alternate names: 4-GalTase 6, 4-galactosyltransferase 6, 4-galactosyltransferase 6, 4-galactosyltransferase 6, Beta-1, Beta-1, Beta4Gal-T6, UDP-Gal:beta-GlcNAc beta-1, UDP-galactose:beta-N- acetylglucosamine beta-1, b4Gal-T6
Gene ID 9331
NCBI Accession NP_004766
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Takizawa, Nomura, Wakisaka et al.: "cDNA cloning and expression of human lactosylceramide synthase." in: Biochimica et biophysica acta, Vol. 1438, Issue 2, pp. 301-4, 1999 (PubMed).

Amado, Almeida, Schwientek et al.: "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions." in: Biochimica et biophysica acta, Vol. 1473, Issue 1, pp. 35-53, 2000 (PubMed).

Fan, Yu, Tu et al.: "Molecular cloning, genomic organization, and mapping of beta 4GalT-VIb, a brain abundant member of beta 4-galactosyltransferase gene family, to human chromosome 18q12.1." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 13, Issue 1, pp. 1-8, 2002 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Landers, Melki, Meininger et al.: "Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 22, pp. 9004-9, 2009 (PubMed).

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