BCL3 antibody (FITC)

Catalog No. ABIN950630

Product Details anti-BCL3 Antibody (FITC)

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Reactivity: Human, Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This BCL3 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: Recognizes B-cell Leukemia/lymphoma 3

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Protein G Affinity Chromatography.

Immunogen: Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma.

Clone: Ham150-3-5

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BCL3

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Alternative Name: Bcl-3 (BCL3 Products)

Synonyms: BCL3 antibody, AI528691 antibody, Bcl-3 antibody, BCL4 antibody, D19S37 antibody, B-cell CLL/lymphoma 3 antibody, B cell leukemia/lymphoma 3 antibody, BCL3 antibody, Bcl3 antibody

Background: B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80 % homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.Synonyms: B-cell lymphoma 3-encoded protein, BCL3, BCL4, D19S37

Gene ID: 602

NCBI Accession: NP_005169

UniProt: P20749

Pathways: NF-kappaB Signaling, Maintenance of Protein Location, Protein targeting to Nucleus