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B-Cell CLL/lymphoma 7A (BCL7A) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN950637, Supplier: Log in to see
Antigen
  • bcl7a
  • MGC89576
  • BCL7A
  • 4432415N06Rik
  • AI448316
  • BCL7
  • cb585
  • id:ibd1097
  • sb:cb585
  • wu:fk02d01
  • zgc:92023
Epitope
N-Term, AA 1-30
16
14
14
6
4
1
Reactivity
Human
46
10
4
3
3
2
1
1
1
Host
Rabbit
31
15
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
43
32
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCL7A
Isotype Ig
Specificity This antibody reacts to Bcl-7A.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name Bcl-7A (BCL7A Antibody Abstract)
Background This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.Synonyms: B-cell CLL/lymphoma 7 protein family member A, BCL7A
Gene ID 605
NCBI Accession NP_001019979
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-B-Cell CLL/lymphoma 7A (BCL7A) (AA 1-30), (N-Term) antibody (ABIN950637) BCL7A Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35µg/lan...
Background publications Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

Liang, Caporaso, McMaster et al.: "Common genetic variants in candidate genes and risk of familial lymphoid malignancies." in: British journal of haematology, Vol. 146, Issue 4, pp. 418-23, 2009 (PubMed).

Morton, Purdue, Zheng et al.: "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 4, pp. 1259-70, 2009 (PubMed).

Carbone, Bernardini, Valenzano et al.: "Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF." in: Genes, chromosomes & cancer, Vol. 47, Issue 12, pp. 1067-75, 2008 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).