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CADM1 antibody (N-Term)

CADM1 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN951001
  • Target See all CADM1 Antibodies
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Binding Specificity
    • 16
    • 10
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 69-98, N-Term
    Reactivity
    • 55
    • 38
    • 27
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 52
    • 3
    • 2
    Rabbit
    Clonality
    • 55
    • 2
    Polyclonal
    Conjugate
    • 28
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CADM1 antibody is un-conjugated
    Application
    • 56
    • 27
    • 18
    • 18
    • 14
    • 14
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human and Mouse.
    Purification
    Affinity chromatography on Protein A
    Immunogen
    KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human CADM1
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CADM1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Alternative Name
    CADM1 / SYNCAM (CADM1 Products)
    Synonyms
    BL2 antibody, IGSF4 antibody, IGSF4A antibody, NECL2 antibody, Necl-2 antibody, RA175 antibody, ST17 antibody, SYNCAM antibody, TSLC1 antibody, sTSLC-1 antibody, sgIGSF antibody, synCAM1 antibody, bl2 antibody, igsf4 antibody, igsf4a antibody, necl-2 antibody, necl2 antibody, ra175 antibody, sgigsf antibody, st17 antibody, stslc-1 antibody, syncam antibody, syncam1 antibody, tslc1 antibody, xnecl2 antibody, 2900073G06Rik antibody, 3100001I08Rik antibody, AI987920 antibody, Bl2 antibody, Igsf4 antibody, Igsf4a antibody, Necl2 antibody, RA175A antibody, RA175B antibody, RA175C antibody, RA175N antibody, SgIGSF antibody, SynCam antibody, Tslc1 antibody, SynCAM1 antibody, cell adhesion molecule 1 antibody, cell adhesion molecule 1 L homeolog antibody, CADM1 antibody, cadm1.L antibody, Cadm1 antibody
    Background
    Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.Synonyms: Cell adhesion molecule 1, IGSF4, IGSF4A, IgSF4, Immunoglobulin superfamily member 4, NECL-2, NECL2, Nectin-like protein 2, SgIgSF, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1
    Molecular Weight
    48509 Da
    Gene ID
    23705
    NCBI Accession
    NP_001091987
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
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