Cancer Susceptibility Candidate 4 (CASC4) (AA 343-373), (C-Term) antibody

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Antigen
  • H63
  • D130060C09Rik
  • VGFG2573
  • cancer susceptibility candidate 4
  • protein casc4
  • CASC4
  • Casc4
  • casc4
Epitope
C-Term, AA 343-373
15
11
4
1
1
1
1
Reactivity
Human, Mouse (Murine)
26
15
3
2
1
1
1
Host
Rabbit
26
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
22
17
15
4
2
2
2
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Immunogen KLH conjugated synthetic peptide between 343-373 amino acids from the C-terminal region of human CASC4
Isotype Ig
Specificity This antibody reacts to CASC4.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name CASC4 (CASC4 Antibody Abstract)
Background The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30 % of human breast and 20 % of human ovarian cancers. Further characterization of the product of this gene may yield insight into the fundamental biology and pathogenetic effects of HER-2/neu overexpression in human breast and ovarian cancer cells. Alternatively spliced variants encoding different isoforms have been identified for this gene.Synonyms: Cancer susceptibility candidate gene 4 protein
Molecular Weight 48864 Da
Gene ID 113201
NCBI Accession NP_612432
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Cancer Susceptibility Candidate 4 (CASC4) (AA 343-373), (C-Term) antibody (ABIN951049) CASC4 Antibody (C-term) western blot analysis in mouse Neuro-2a cell line lysat...
Background publications Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Sato, Peiper, Heinecke, Zurakowski, Eisenberger, Hosch, Knoefel, Izbicki: "Expression of HER2/neu does not correlate with survival in soft tissue sarcoma." in: Onkologie, Vol. 26, Issue 3, pp. 268-71, 2003 (PubMed).

Scheer, Prange, Petmecky, Schirmacher, Zöller, Kübler: "[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 138-45, 2003 (PubMed).

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).