Cancer Susceptibility Candidate 4 (CASC4) (C-Term), (AA 343-373) antibody

Details for Product No. ABIN951049
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Antigen
Synonyms H63, D130060C09Rik, VGFG2573
Epitope
C-Term, AA 343-373
(9), (7), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(13), (3)
Host
Rabbit
(13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(13), (9), (7), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN951049
357.50 $
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Immunogen KLH conjugated synthetic peptide between 343-373 amino acids from the C-terminal region of human CASC4
Isotype Ig
Specificity This antibody reacts to CASC4.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name CASC4
Background The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30 % of human breast and 20 % of human ovarian cancers. Further characterization of the product of this gene may yield insight into the fundamental biology and pathogenetic effects of HER-2/neu overexpression in human breast and ovarian cancer cells. Alternatively spliced variants encoding different isoforms have been identified for this gene.Synonyms: Cancer susceptibility candidate gene 4 protein
Molecular Weight 48864 Da
Gene ID 113201
NCBI Accession NP_612432
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Scheer, Prange, Petmecky et al.: "[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 138-45, 2003 (PubMed).

Sato, Peiper, Heinecke et al.: "Expression of HER2/neu does not correlate with survival in soft tissue sarcoma." in: Onkologie, Vol. 26, Issue 3, pp. 268-71, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

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