BST1 antibody

Catalog No. ABIN951197

Product Details anti-BST1 Antibody

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This BST1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: This Monoclonal Antibody reacts with Mouse CD157.

Purification: Protein G Chromatography

Immunogen: T cell hybridoma J774. Donor: Balb/c mouse spleen cells. Fusion Partner: NSO Mouse Myelom a Partner.

Clone: KT157

Isotype: IgG2c

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BST1

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Alternative Name: CD157 / BST1 (BST1 Products)

Synonyms: BST1 antibody, 114/A10 antibody, A530073F09 antibody, BP-3 antibody, Bp3 antibody, Bsta1 antibody, CD157 antibody, Ly65 antibody, bone marrow stromal cell antigen 1 antibody, BST1 antibody, Bst1 antibody

Background: CD157 also known as BP-3 Alloantigen or Bone marrow Stromal cell antigen-1 (BST-1), is a 38-48 KDa differentially glycosylated glycosylphosphatidylinositol (GPI) anchored cell surface glycoprotein. CD157, like CD38 belongs to a family of genetically related pleiotropic ectoenzymes. The CD157 antigen is expressed on thymocytes, bone marrow B cells, neutrophils, macrophages, stromal cells, intestinal epithelial cells, the collecting tubules of the kidney and reticular cells in lymph nodes. The CD157 receptor has ADP ribosyl cyclase and cyclic ADP ribose hydrolase biochemical activities. Studies show CD157 is a receptor that induces reorganization of the cytoskeleton and significant changes in cell shape. CD157 is also a mediator of neutrophil adhesion and migration. Signals mediated by CD157 act through modulation of cytosolic [Ca2+]. CD157 is also involved in cellular adhesion to the extracellular matrix.Synonyms: ADP-ribosyl cyclase 2, BST-1, Bone marrow stromal antigen 1, Cyclic ADP-ribose hydrolase 2, cADPr hydrolase 2

Gene ID: 12182

NCBI Accession: NP_033893

UniProt: Q64277