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TEK antibody (TEK Tyrosine Kinase, Endothelial) (AA 19-745)

Details for Product anti-TEK Antibody No. ABIN951221, Supplier: Log in to see
Antigen
  • AA517024
  • CD202B
  • Cd202b
  • DKFZp469E064
  • Hyk
  • TEK
  • Tie-2
  • TIE-2
  • tie-2
  • TIE2
  • tie2
  • Tie2
  • VMCM
  • VMCM1
Alternatives
anti-Human TEK antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 19-745
29
23
22
20
19
17
13
10
9
7
6
6
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
251
125
71
6
6
2
2
1
Host
Rabbit
175
81
24
3
2
2
Clonality
Polyclonal
Conjugate
This TEK antibody is un-conjugated
20
15
13
8
8
8
6
4
4
4
4
4
4
4
4
Application
Western Blotting (WB)
153
130
60
45
44
25
20
15
12
9
7
6
4
4
3
1
Supplier
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Immunogen Highly pure (>95%) recombinant Human soluble TIE-2 (Thr19-Lys745) derived from Insect cells.
Isotype IgG
Specificity Recognizes TIE-2 (CD202b/TEK)
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Protein A Chromatography
Alternative Name CD202b / TEK (TEK Antibody Abstract)
Background TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/TEK comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or TIE-2 display similar angiogenic defects.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
Gene ID 7010
NCBI Accession NP_000450
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, pH 7.2
Storage 4 °C/-20 °C
Storage Comment The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TEK antibody (TEK Tyrosine Kinase, Endothelial) (AA 19-745) (ABIN951221) Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal ...
Background publications Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999

Procopio, Pelavin, Lee, Yeilding: "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30196-201, 1999

Takakura, Huang, Naruse, Hamaguchi, Dumont, Yancopoulos, Suda: "Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis." in: Immunity, Vol. 9, Issue 5, pp. 677-86, 1998