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CD27 Molecule (CD27) antibody (FITC)

Details for Product No. ABIN951255, Supplier: Login to see
Antigen
  • TNFRSF7
  • S152
  • Tnfrsf7
  • Tp55
  • S152. LPFS2
  • T14
Reactivity
Mouse (Murine)
298
110
52
4
4
4
2
1
Host
Hamster
180
81
44
32
9
3
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
42
41
25
22
10
6
6
6
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
262
67
66
43
34
20
19
18
12
11
8
5
2
2
2
1
1
1
1
1
Supplier
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Immunogen MCD27 tag expressing clones AR0524 and AR0530 from Armenian Hamster spleen.
Clone LG-3A10
Isotype IgG1
Specificity Recognizes Mouse CD27 receptor.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Protein G Chromatography.
Alternative Name CD27 (CD27 Antibody Abstract)
Background CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both αβ and γδ T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8- precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7
Gene ID 21940
NCBI Accession NP_001028298
UniProt P41272
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Cytokines, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % Sodium Azide, EIA grade BSA to bring total protein concentration to 4-5 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light.
Supplier Images
Flow Cytometry (FACS) image for anti-CD27 Molecule (CD27) antibody (FITC) (ABIN951255) anti-CD27 Molecule (CD27) antibody (FITC)
Background publications Henke, Launhardt, Klement et al.: "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva." in: Journal of virology, Vol. 74, Issue 9, pp. 4284-90, 2000 (PubMed).

Gravestein, Nieland, Kruisbeek et al.: "Novel mAbs reveal potent co-stimulatory activity of murine CD27." in: International immunology, Vol. 7, Issue 4, pp. 551-7, 1995 (PubMed).