CD27 antibody (CD27 Molecule) (PE)

Details for Product anti-CD27 Antibody No. ABIN951257, Supplier: Log in to see
Antigen
  • TNFRSF7
  • S152
  • Tnfrsf7
  • Tp55
  • S152. LPFS2
  • T14
  • CD27 molecule
  • CD27 antigen
  • CD27
  • Cd27
Alternatives
anti-Mouse (Murine) CD27 antibody for Cytometry by Time of Flight
Reactivity
Mouse (Murine)
450
173
67
8
8
8
6
3
2
2
2
1
1
1
Host
Hamster
281
101
60
43
38
6
Clonality (Clone)
Monoclonal ()
Conjugate
This CD27 antibody is conjugated to PE
53
50
32
25
14
14
13
13
11
10
10
8
7
7
7
7
6
6
6
6
5
5
5
5
5
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
432
80
68
63
60
48
47
28
19
16
13
8
5
4
3
3
2
2
2
2
2
1
1
1
1
Options
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Immunogen MCD27 tag expressing clones AR0524 and AR0530 Donor: Armenian hamster spleen Fusion Partner: SP2/0 Murine Myeloma Partner
Clone LG-3A10
Isotype IgG1
Specificity This Monoclonal Antibody is specific for the Mouse CD27 receptor.
Alternative Name CD27 (CD27 Antibody Abstract)
Background CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both αβ and γδ T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8-precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7
Gene ID 21940
NCBI Accession NP_001028298
UniProt P41272
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Cytokines, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0,1 mg/mL
Buffer PBS, 0.02 % Sodium Azide, EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-CD27 antibody (CD27 Molecule)  (PE) (ABIN951257) anti-CD27 Molecule (CD27) antibody (PE)
Background publications Henke, Launhardt, Klement, Stelzner, Zell, Munder: "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva." in: Journal of virology, Vol. 74, Issue 9, pp. 4284-90, 2000 (PubMed).

Gravestein, Nieland, Kruisbeek, Borst: "Novel mAbs reveal potent co-stimulatory activity of murine CD27." in: International immunology, Vol. 7, Issue 4, pp. 551-7, 1995 (PubMed).