Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (C-Term), (AA 216-246) antibody

Details for Product No. ABIN951266
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Antigen
Synonyms ICOSLG, AU044799, B7-H2, B7RP-1, B7h, BG071784, GI50, GL50, GL50-B, ICOS-L, Icoslg, LICOS, Ly115l, mKIAA0653, B7H2, B7RP1, CD275, ICOSL, Icosl, RGD1562791
Epitope
C-Term, AA 216-246
(8), (8), (7), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(85), (60), (17)
Host
Rabbit
(62), (43), (21), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (13), (8), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
ELISA, Western Blotting (WB)
(70), (37), (31), (24), (13), (8), (5), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951266
357.50 $
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Immunogen KLH conjugated synthetic peptide between 216-246 amino acids from the C-terminal region of human CD275 / ICOS Ligand
Specificity This antibody recognizes Human CD275 / ICOS Ligand (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name CD275 / ICOS Ligand
Background Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T- cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Alternate names: B7 homolog 2, B7-like protein Gl50, B7-related protein 1, B7H2, B7RP-1, B7RP1, ICOSL, ICOSLG, KIAA0653
Molecular Weight 33349 Da
Gene ID 23308
NCBI Accession NP_056074
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Wang, Baldassano, Zhang et al.: "Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects." in: Human molecular genetics, Vol. 19, Issue 10, pp. 2059-67, 2010 (PubMed).

Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression...." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Pan, Yang, Chen et al.: "Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function." in: Immunogenetics, Vol. 62, Issue 4, pp. 237-51, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

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