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Toll-Like Receptor 9 (TLR9) antibody

Details for Product No. ABIN951281
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Antigen
Synonyms CD289
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(151), (81), (34), (15), (14), (13), (2), (1), (1)
Host
Rabbit
(102), (52), (16), (8), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(17), (12), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(144), (76), (60), (48), (33), (32), (21), (10), (6), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN951281
368.50 $
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Immunogen Peptide corresponding to 15 amino acids near the center of human TLR9
Isotype IgG
Specificity This antibody detects TLR9. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver (6).
Purification Purified
Alternative Name CD289 / TLR9
Background Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). TLR9 forms a subfamily along with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences (3) and are localized in intracellular acidic compartments such as the phagolysosome (4). Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection (5), TLR9 is strictly dependent on MyD88 (3).
Alternate names: Toll-like receptor 9, UNQ5798/PRO19605
Gene ID 54106
NCBI Accession NP_059138.1
UniProt Q9NR96
Research Area Signaling, Immunology, Inflammation
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline with 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Expiry Date 12 months
Supplier Images
anti-Toll-Like Receptor 9 (TLR9) antibody anti-Toll-Like Receptor 9 (TLR9) antibody
Background publications Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Nishiya, DeFranco: "Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 19008-17, 2004 (PubMed).

Wagner: "The immunobiology of the TLR9 subfamily." in: Trends in immunology, Vol. 25, Issue 7, pp. 381-6, 2004 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Validation Images
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