CD5 Molecule (CD5) antibody (PE)

Details for Product No. ABIN951345
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Antigen
Synonyms CD5, Ly-1, Ly-12, Ly-A, Lyt-1, LEU1, T1
Reactivity
Human, Mouse (Murine)
(335), (167), (82), (39), (28), (25), (19), (12), (9), (1), (1)
Host
Rat
(367), (122), (97)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(96), (64), (62), (25), (14), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(419), (117), (94), (83), (82), (76), (50), (36), (20), (19), (13), (11), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN951345
253.00 $
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Immunogen Mouse thymus or spleen from Balb/c mouse thymus or spleen.
Clone 53-7-3
Isotype IgG2a
Specificity This CD5 (Ly-1) Monoclonal Antibody is specific for the Mouse CD5 antigen.
Purification Protein G Chromatography
Alternative Name CD5
Background CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Alternate names: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
Gene ID 12507
NCBI Accession NP_031676
UniProt P13379
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Ledbetter, Rouse, Micklem et al.: "T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views." in: The Journal of experimental medicine, Vol. 152, Issue 2, pp. 280-95, 1980 (PubMed).

van Ewijk, van Soest, van den Engh: "Fluorescence analysis and anatomic distribution of mouse T lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2, and T-200." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 127, Issue 6, pp. 2594-604, 1982 (PubMed).

Raman, Kuo, Deshane et al.: "Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5." in: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 19183-9, 1998 (PubMed).

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