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Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody

Details for Product No. ABIN951417, Supplier: Log in to see
Antigen
  • CD85H
  • ILT1
  • LIR-7
  • LIR7
Epitope
AA 62-89, Middle Region
18
15
9
5
3
2
2
2
1
1
1
1
Reactivity
Human
50
Host
Rabbit
40
9
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
41
35
16
1
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of Human CD85h / LILRA2
Isotype Ig
Specificity This antibody recognizes Human CD85h / LILRA2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name CD85h / LILRA2 (LILRA2 Antibody Abstract)
Background Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3, MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.Synonyms: CD85 antigen-like family member H, ILT-1, ILT1, Immunoglobulin-like transcript 1, LILRA-2, LIR-7, LIR7, Leukocyte immunoglobulin-like receptor 7, Leukocyte immunoglobulin-like receptor subfamily A member 2
Molecular Weight 52992 Da
Gene ID 11027
NCBI Accession NP_001124389
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody (ABIN951417) Flow cytometric analysis of A549 cells using CD85h / LILRA2 Antibody (Center) Cat.-No...
Western Blotting (WB) image for anti-Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 2 (LILRA2) (AA 62-89), (Middle Region) antibody (ABIN951417) Western blot analysis of CD85h / LILRA2 Antibody (Center) in NCI-H292,NCI-H460 and A5...
Background publications Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Jones, Roghanian, Brown et al.: "Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes." in: European journal of immunology, Vol. 39, Issue 11, pp. 3195-206, 2010 (PubMed).

Chen, Gao, Chu et al.: "Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes." in: Journal of molecular biology, Vol. 386, Issue 3, pp. 841-53, 2009 (PubMed).

Mamegano, Kuroki, Miyashita et al.: "Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis." in: Genes and immunity, Vol. 9, Issue 3, pp. 214-23, 2008 (PubMed).

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