CCR8 antibody (C-Term)

Catalog No. ABIN951452

Product Details anti-CCR8 Antibody

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Binding Specificity: AA 297-325, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR8 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CCR8.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 297-325 amino acids from the C-terminal region of human CCR8

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CCR8

Target: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Alternative Name: CDw198 / CCR8 (CCR8 Products)

Synonyms: CC-CKR-8 antibody, CCR-8 antibody, CDw198 antibody, CKRL1 antibody, CMKBR8 antibody, CMKBRL2 antibody, CY6 antibody, GPRCY6 antibody, TER1 antibody, C-C antibody, C-C CKR-8 antibody, CKR-8 antibody, Cmkbr8 antibody, mCCR8 antibody, C-C motif chemokine receptor 8 antibody, chemokine (C-C motif) receptor 8 antibody, CCR8 antibody, Ccr8 antibody

Background: CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.Synonyms: C-C CKR-8, C-C chemokine receptor type 8, CC-CKR-8, CC-chemokine receptor CHEMR1, CCR-8, CKRL1, CMKBR8, CMKBRL2, Chemokine receptor-like 1, GPR-CY6, TER1

Molecular Weight: 40844 Da

Gene ID: 1237

NCBI Accession: NP_005192