COL1A2 antibody (Chain alpha 2, N-Term)

Catalog No. ABIN951621

Product Details anti-COL1A2 Antibody

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Binding Specificity: AA 23-51, Chain alpha 2, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL1A2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to COL1A2.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human COL1A2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for COL1A2

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Abstract: COL1A2 Products

Synonyms: AA960264 antibody, AI325291 antibody, Col1a-2 antibody, Cola-2 antibody, Cola2 antibody, oim antibody, OI4 antibody, Gas-6 antibody, alpha2(I) antibody, hm:zehn2357 antibody, wu:fa98d05 antibody, wu:fa99g10 antibody, wu:fb04c08 antibody, wu:fb11d06 antibody, zehn2357 antibody, coagulation factor II, thrombin antibody, collagen, type I, alpha 2 antibody, collagen type I alpha 2 chain antibody, collagen type I alpha 2 L homeolog antibody, growth arrest specific 6 antibody, F2 antibody, Col1a2 antibody, col1a2.L antibody, COL1A2 antibody, Gas6 antibody, col1a2 antibody

Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].Synonyms: Alpha-2 type I collagen, COL1A2

Molecular Weight: 129314 Da

Gene ID: 1278

NCBI Accession: NP_000080