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COPS7A antibody (COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)) (C-Term)

Details for Product anti-COPS7A Antibody No. ABIN951662, Supplier: Log in to see
Antigen
  • CSN7A
  • D6Ertd35e
Alternatives
anti-Human COPS7A antibody for Western Blotting
Epitope
C-Term, AA 244-274
19
15
4
2
2
1
1
1
1
Reactivity
Human
54
29
23
2
Host
Rabbit
53
1
Clonality
Polyclonal
Conjugate
This COPS7A antibody is un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
36
22
22
11
6
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 244-274 amino acids from the C-terminal region of human COPS7A
Isotype Ig
Specificity This antibody reacts to COPS7A.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name COPS7A (COPS7A Antibody Abstract)
Background Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.Synonyms: COP9 signalosome complex subunit 7a, CSN7A, DERP10, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, SGN7a, Signalosome subunit 7a
Molecular Weight 30277 Da
Gene ID 50813
NCBI Accession NP_001157565
Pathways Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-COPS7A antibody (COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)) (C-Term) (ABIN951662) COPS7A Antibody (C-term) immunohistochemistry analysis in formalin fixed and pa...
Western Blotting (WB) image for anti-COPS7A antibody (COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)) (C-Term) (ABIN951662) COPS7A Antibody (C-term) western blot analysis in human placenta tissue lysates...
Background publications Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005

Obuse, Iwasaki, Kiyomitsu, Goshima, Toyoda, Yanagida: "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1." in: Nature cell biology, Vol. 6, Issue 11, pp. 1135-41, 2004

Wolf, Zhou, Wee: "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?" in: Nature cell biology, Vol. 5, Issue 12, pp. 1029-33, 2003

Groisman, Polanowska, Kuraoka, Sawada, Saijo, Drapkin, Kisselev, Tanaka, Nakatani: "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage." in: Cell, Vol. 113, Issue 3, pp. 357-67, 2003