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Cortactin antibody (N-Term)
CTTN
Reactivity: Human
WB, IHC (p), EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Cortactin Antibody
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Target
See all Cortactin (CTTN) Antibodies
Cortactin (CTTN)
Binding Specificity
All epitopes for Cortactin antibodies
AA 16-46, N-Term
Reactivity
All reactivities for Cortactin antibodies
Human
Host
All hosts for Cortactin antibodies
Rabbit
Clonality
All clonalities for Cortactin antibodies
Polyclonal
Conjugate
All conjugates for Cortactin antibodies
This Cortactin antibody is un-conjugated
Application
All applications for Cortactin antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Specificity
This antibody recognizes Cortactin (SRC8) at N-term.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Purified through a Protein A column followed by peptide affinity purification
Immunogen
Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 16-46aa) of human Cortactin (SRC8)
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) Sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Cortactin
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Target
Cortactin (CTTN)
Alternative Name
Cortactin (CTTN Products )
Synonyms
EMS1 antibody, 1110020L01Rik antibody, Ems1 antibody, Cttnb antibody, CG3637 antibody, Dmel\CG3637 antibody, cortactin antibody, cttn antibody, CTTN1 antibody, P85.25 antibody, Cttn antibody, ems1 antibody, CTTN antibody, cortactin antibody, CG3637 gene product from transcript CG3637-RD antibody, cortactin S homeolog antibody, cortactin L homeolog antibody, src substrate cortactin antibody, Src substrate cortactin antibody, CTTN antibody, Cttn antibody, Cortactin antibody, cttn.S antibody, cttn.L antibody, cttn antibody, CpipJ_CPIJ006351 antibody, Bm1_57220 antibody, LOC100533277 antibody
Background
SRC8 (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.Synonyms: Amplaxin, CTTN, EMS1, Oncogene EMS1
Gene ID
2017
NCBI Accession
NP_005222
Pathways
MAPK Signaling
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