Cytohesin 3 antibody (CYTH3) (C-Term)

Details for Product anti-CYTH3 Antibody No. ABIN951804, Supplier: Log in to see
Antigen
  • CYTH3
  • PSCD3
  • pscd3
  • MGC145373
  • ARNO3
  • GRP1
  • AI648983
  • CLM3
  • Grp1
  • Pscd3
  • Sec7
  • Sec7C
  • cytohesin 3
  • Cytohesin 3
  • CYTH3
  • cyth3
  • Bm1_39360
  • Cyth3
Epitope
C-Term, AA 371-400
17
11
10
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
43
24
12
2
1
Host
Rabbit
33
13
Clonality
Polyclonal
Conjugate
This Cytohesin 3 antibody is un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
42
33
8
6
3
2
2
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 371~400 amino acids from the C-terminal region of Human CYTH3. Genename: CYTH3
Isotype Ig
Specificity This antibody recognizes Human and Mouse Cytohesin 3 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name Cytohesin 3 (CYTH3 Antibody Abstract)
Background This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.Synonyms: ARF nucleotide-binding site opener 3, ARNO3, CYTH3, GRP1, General receptor of phosphoinositides 1, PH, PSCD3, SEC7 and coiled-coil domain-containing protein 3
Molecular Weight 46349 Da
Gene ID 9265
NCBI Accession NP_004218
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Cytohesin 3 (CYTH3) (AA 371-400), (C-Term) antibody (ABIN951804) Western blot analysis of Cytohesin 3 Antibody (C-term) in Hela cell line lysates (35u...
Western Blotting (WB) image for anti-Cytohesin 3 (CYTH3) (AA 371-400), (C-Term) antibody (ABIN951804) Western blot analysis of Cytohesin 3 Antibody (C-term) in Mouse cerebellum tissue lys...
Background publications Morishige, Hashimoto, Ogawa, Toda, Kotani, Hirose, Wei, Hashimoto, Yamada, Yano, Mazaki, Kodama, Nio, Manabe, Wada, Kobayashi, Sabe: "GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion." in: Nature cell biology, Vol. 10, Issue 1, pp. 85-92, 2008 (PubMed).

Poirier, Hamann, Domingue, Roy, Bardati, Langlois: "General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding." in: Molecular endocrinology (Baltimore, Md.), Vol. 19, Issue 8, pp. 1991-2005, 2005 (PubMed).

Ogasawara, Kim, Adamik, Togawa, Ferrans, Takeda, Kirby, Moss, Vaughan: "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3221-30, 2000 (PubMed).

Nevrivy, Peterson, Avram, Ishmael, Hansen, Dowell, Hruby, Dawson, Leid: "Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16827-36, 2000 (PubMed).

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