Keratin 7 (KRT7) antibody

Details for Product No. ABIN951823
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Antigen
Synonyms CK7, K2C7, K7, SCL, D15Wsu77e, Krt2-7, KRT7
Reactivity
Human
(198), (47), (43), (8), (7), (7), (4), (4), (4), (3), (1), (1), (1)
Host
Mouse
(117), (104), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (7), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(161), (96), (59), (52), (50), (39), (39), (37), (20), (13), (13), (10), (3), (3), (2), (1)
Pubmed 5 references available
Quantity 1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN951823
335.50 $
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Immunogen OTN II ovarian carcinoma cell line.
Clone OVTL-12-30
Isotype IgG1
Specificity Antibody to Cytokeratin is useful in distinguishing ovarian carcinomas (keratin 7+) from colon carcinomas (keratin 7-). OVTL 12-30 decorates specific subtypes of adenocarcinoma.
Cellular Localization: cytoplasmic.
No Cross-Reactivity Rat (Rattus)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name Cytokeratin 7
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Keratin K7 is found in the columnar and glandular epithelium of the lung, cervix, breast, bile ducts, larger collecting ducts of the kidney and in mesothelium, but is normally absent from gastrointestinal epithelium, hepatocytes and myoepithelium. Several types of adenocarcinomas of the urinary tract are negative, while adenocarcinomas of the mammary gland, ovary and lung are positive. In colorectal carcinoma early stages are reported to be negative but advanced stages of tumor development are positive for keratin K7 expression.Synonyms: CK-7, CK7, K-7, K7, KRT-7, KRT7, Keratin type II cytoskeletal 7, Keratin-7, SCL, Sarcolectin
Gene ID 54474
NCBI Accession NP_061883
UniProt P08729
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or at -20 °C for longer.
Background publications Ramaekers, van Niekerk, Poels et al.: "Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas." in: The American journal of pathology, Vol. 136, Issue 3, pp. 641-55, 1990 (PubMed).

Crooks: "The pathological concept of diffuse axonal injury; its pathogenesis and the assessment of severity." in: The Journal of pathology, Vol. 165, Issue 1, pp. 5-10, 1991 (PubMed).

van Niekerk, Boerman, Ramaekers et al.: "Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas." in: The American journal of pathology, Vol. 138, Issue 2, pp. 455-63, 1991 (PubMed).

van de Molengraft, van Niekerk, Jap et al.: "OV-TL 12/30 (keratin 7 antibody) is a marker of glandular differentiation in lung cancer." in: Histopathology, Vol. 22, Issue 1, pp. 35-8, 1993 (PubMed).

Nanashima, Tagawa, Yasutake et al.: "Deletion of chromosome 11 and development of colorectal carcinoma." in: Cancer detection and prevention, Vol. 21, Issue 1, pp. 7-11, 1997 (PubMed).

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