GBA3 antibody (C-Term)

Catalog No. ABIN951831

Product Details anti-GBA3 Antibody

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Binding Specificity: AA 295-325, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Cytosolic beta-glucosidase (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 295-325 amino acids from the C-terminal region of Human Cytosolic beta-glucosidase Genename: GBA3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GBA3

Target: GBA3 (Glucosidase, Beta, Acid 3 (Cytosolic) (GBA3))

Alternative Name: Cytosolic beta-Glucosidase (GBA3 Products)

Synonyms: im:6912508 antibody, CBG antibody, CBGL1 antibody, GLUC antibody, KLRP antibody, glucosylceramidase beta 3 antibody, glucosidase, beta, acid 3 (gene/pseudogene) antibody, glucosidase, beta, acid 3 (cytosolic) antibody, cytosolic beta-glucosidase antibody, glucosylceramidase beta 3 (gene/pseudogene) antibody, Gba3 antibody, gba3 antibody, GBA3 antibody, LOC100344458 antibody

Background: GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).Synonyms: CBG, CBGL1, Cytosolic beta-glucosidase-like protein 1, GBA3

Molecular Weight: 53696 Da

Gene ID: 57733

NCBI Accession: NP_001121904