Dishevelled, Dsh Homolog 2 (Drosophila) (DVL2) (C-Term), (AA 587-617) antibody

Details for Product No. ABIN951919
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Antigen
Synonyms zgc:55372, wu:fc05d12, wu:fo71e09, wu:fp54a02, Dvl-2, dishevelled, dsh, dvl, xdsh, Xdsh
Epitope
C-Term, AA 587-617
(12), (12), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(54), (42), (40), (25), (25), (24), (12), (2), (1), (1)
Host
Rabbit
(55), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
ELISA, Western Blotting (WB)
(30), (27), (13), (10), (7), (3), (2), (2)
Pubmed 4 references available
Catalog no. ABIN951919
Quantity 0.4 mL
Price
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Immunogen KLH conjugated synthetic peptide between 587-617 amino acids from the C-terminal region of Human DVL2.
Specificity This antibody recognizes Human Dishevelled-2 / DVL2 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name Dishevelled-2 / DVL2
Background This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Alternate names: DSH homolog 2, DVL-2, Segment polarity protein dishevelled homolog DVL-2
Molecular Weight 78948 Da
Gene ID 1856
NCBI Accession NP_004413
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Gao, Cao, Bao et al.: "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation." in: Nature cell biology, Vol. 12, Issue 8, pp. 781-90, 2010 (PubMed).

Kikuchi, Niikura, Kitagawa et al.: "Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1." in: The EMBO journal, Vol. 29, Issue 20, pp. 3470-83, 2010 (PubMed).

Ohashi, Yamamoto, Horiguchi et al.: "Association between visceral adipose tissue area and coronary plaque morphology assessed by CT angiography." in: JACC. Cardiovascular imaging, Vol. 3, Issue 9, pp. 908-17, 2010 (PubMed).

Hosts (55), (2)
Reactivities (54), (42), (40), (25), (25), (24), (12), (2), (1), (1)
Applications (30), (27), (13), (10), (7), (3), (2), (2)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (12), (12), (3), (2), (2), (2), (1), (1)
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