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DVL2 antibody (Dishevelled, Dsh Homolog 2 (Drosophila)) (C-Term)

Details for Product anti-DVL2 Antibody No. ABIN951919, Supplier: Log in to see
Antigen
  • dishevelled
  • dsh
  • dvl
  • Dvl-2
  • wu:fc05d12
  • wu:fo71e09
  • wu:fp54a02
  • xdsh
  • Xdsh
  • zgc:55372
Epitope
C-Term, AA 587-617
20
15
14
13
13
13
4
4
3
3
2
2
1
1
1
Reactivity
Human
93
41
36
2
2
2
2
1
1
1
1
1
Host
Rabbit
78
18
Clonality
Polyclonal
Conjugate
This DVL2 antibody is un-conjugated
5
5
4
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
58
26
22
15
11
7
4
Supplier
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Immunogen KLH conjugated synthetic peptide between 587-617 amino acids from the C-terminal region of Human DVL2.
Isotype Ig
Specificity This antibody recognizes Human Dishevelled-2 / DVL2 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name Dishevelled-2 / DVL2 (DVL2 Antibody Abstract)
Background This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40 % amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.Synonyms: DSH homolog 2, DVL-2, Segment polarity protein dishevelled homolog DVL-2
Molecular Weight 78948 Da
Gene ID 1856
NCBI Accession NP_004413
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-DVL2 antibody (Dishevelled, Dsh Homolog 2 (Drosophila)) (C-Term) (ABIN951919) Western blot analysis of Dishevelled-2 / DVL2 Antibody (C-term) in CEM cell line lysa...
Background publications Kikuchi, Niikura, Kitagawa, Kikuchi: "Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1." in: The EMBO journal, Vol. 29, Issue 20, pp. 3470-83, 2010

Gao, Cao, Bao, Zuo, Xie, Cai, Fu, Zhang, Wu, Zhang, Chen: "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation." in: Nature cell biology, Vol. 12, Issue 8, pp. 781-90, 2010

Ohashi, Yamamoto, Horiguchi, Kitagawa, Kunita, Utsunomiya, Oka, Kohno, Kihara: "Association between visceral adipose tissue area and coronary plaque morphology assessed by CT angiography." in: JACC. Cardiovascular imaging, Vol. 3, Issue 9, pp. 908-17, 2010

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010