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Deoxynucleotidyltransferase, terminal (DNTT) (AA 445-475), (C-Term) antibody

Details for Product No. ABIN951960, Supplier: Log in to see
Antigen
  • TdT
  • TDT
  • BB160593
  • Tdt
  • dntt-A
  • dntt
Alternatives
anti-Human Deoxynucleotidyltransferase, terminal antibody for Immunohistochemistry
Epitope
C-Term, AA 445-475
37
33
15
15
9
3
3
3
3
2
2
2
2
2
1
1
1
Reactivity
Human
132
31
24
7
5
3
2
1
Host
Rabbit
109
29
Clonality
Polyclonal
Conjugate
Un-conjugated
9
6
5
4
4
4
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
93
50
22
14
10
9
6
4
4
4
2
2
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 445-475 amino acids from the C-terminal region of human TdT
Isotype Ig
Specificity This antibody detects DNTT / TDT (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name DNTT / TDT (DNTT Antibody Abstract)
Background This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.Synonyms: DNA nucleotidylexotransferase, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase
Gene ID 1791
NCBI Accession NP_001017520
Pathways DNA Damage Repair
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Deoxynucleotidyltransferase, terminal (DNTT) (AA 445-475), (C-Term) antibody (ABIN951960) TdT Antibody (C-term) western blot analysis in K562 cell line lysates (35 µg/lane). T...
Background publications Kubota, Maezawa, Koiwai et al.: "Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 12, Issue 8, pp. 941-59, 2007 (PubMed).

OMalley, Orazi: "Terminal deoxynucleotidyl transferase-positive cells in spleen, appendix and branchial cleft cysts in pediatric patients." in: Haematologica, Vol. 91, Issue 8, pp. 1139-40, 2006 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Thai, Kearney: "Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 6, pp. 4009-19, 2004 (PubMed).

Liu, McGavran, Lovell et al.: "Nonpositive terminal deoxynucleotidyl transferase in pediatric precursor B-lymphoblastic leukemia." in: American journal of clinical pathology, Vol. 121, Issue 6, pp. 810-5, 2004 (PubMed).